In pursuit of the Barrow-Dyad Exotic submachine gun in Destiny 2, you must venture into the depths of the Dreadnaught and complete the Derealize Exotic mission. This mission features a few boss fights, a puzzle, and a large traversal area.
Here’s a complete walkthrough of the Derealize Exotic mission in Destiny 2.
How to defeat Vrhiisk, Seeker of Power in the Derealize Exotic mission in Destiny 2

The opening part of the mission is very straightforward. Fight the Dread and use the portal to teleport to the Trenchway. In the boss fight against the Vrhiisk, Seeker of Power, kill Blight Sentinels to spawn the Taken Curse. Pick up and power the Taken Curse by defeating targets like you did before and dunk it where the marker tells you to.
At the end of the fight, the boss will pull you into a bubble, similar to the Shade of Oryx fight during the King’s Fall raid. Defeat the boss, and you’ll be presented with the NO ESCAPE objective and a puzzle to solve.
How to solve the puzzle in the Derealize Exotic mission in Destiny 2

There are five Hive symbols on the wall and a plate with an arrow pointing to the side. To solve the puzzle, you must enter symbols in the sequence displayed on the wall. Stand on the plate and look at the rune. If that’s the rune you need, move off the plate in the direction the plate is pointing. If it’s not the one you need, stand on the plate until the timer expires.
The timer during this puzzle doesn’t wipe you. It simply teleports you to the room with the next symbol. Enter all five symbols to solve the puzzle and escape the bubble.
How to reach the final boss in the Derealize Exotic mission in Destiny 2

Next, it’s time for a long traversal section. Keep following the path, and remember to pull out your ghost to reveal any hidden platforms. Collect the Taken Osseous Fragment and drop down the hole in the wall that was previously blocked by the blight.

Climb up the ledges and keep going until you reach the open space with giant Shriekers. Throughout the traversal section, be mindful of holes in the walls, as you might get nailed (literally). Once you cross the room through the Shrieker and enter another narrow section with nails, there’s a Hive crystal at the end. Destroy it.

Cross the room once more to reach the Hive barrier with seals. Find two more Hive crystals, one at the top and one at the bottom of this room, and destroy them. Keep going until you reach a Hive Tomb ship. Follow the tentacles and jump on flying Taken blights to climb on top of the ship.
Go through the door. At the end of the room, there’s a table with the Barrow-Dyad submachine gun for you to claim.
How to defeat Xir-Kuur in the Derealize Exotic mission in Destiny 2

The job’s not over, though. You need to fight the final boss(es), Xir-Kuur. Deal damage to the boos until it teleports you into the Taken realm. Then, deal damage to the Taken version of the boss and shoot the blights to get back to the normal realm. Rinse and repeat until the game prompts you to get out of the room. Stand on the plate outside and hold it as long as you can to seal the door and lock Xir-Kuur in its room.